The year 2020 was rich in developments and innovations in the field of thrombotic and hemorrhagic disorders. With respect to both its complex physiopathology and its multifaceted antithrombotic treatment, the coagulopathy linked to COVID-19 has aroused major interest that is far from being exhausted. Direct oral anticoagulants (DOACs) continue to be developed and validated, particularly in cancer-related venous thromboembolic diseases and for managing heparin-induced thrombocytopenia. The data on the DOAC use in early pregnancy appear reassuring. While these agents should indeed be avoided during pregnancy, the available data do not justify voluntary pregnancy termination as based on DOAC exposure alone. Mortality in catastrophic anti-phospholipid syndrome (CAPS) is likely to be significantly reduced when two antibodies, consisting of eculizumab and rituximab, are incorporated into the treatment regimen. As regards congenital hemophilia, the publication of new international recommendations by the World Federation of Hemophilia has attracted a great deal of attention, as have new therapeutic advances, including the validation of an ultra-long half-life FVIII concentrate (BIV001). Emicizumab is a bispecific antibody mimicking the action of FVIII that appears to be very promising. In addition to this drug’s use in managing congenital hemophilia A, it is also indicated in managing acquired hemophilia A.

Despite the worldwide health crisis, different advances were made in pediatric cardiology in 2020. This paper discusses six different topics, the first being related to the ongoing pandemic and the last one being a review of the last two decades’ advances made in this field.

During the SARS-CoV-2 pandemic, an unexpected high number of children were admitted, presenting with Kawasaki disease and coronary dilatation. Moreover, in 2021, a new clinical entity arose, which is referred to as multisystem inflammatory syndrome, which was temporarily associated to COVID-19 (MIS-C).This new clinical condition shared similarities with atypical Kawasaki disease, even though the patients’ median age tended to be higher, while a significant left ventricular dysfunction was mostly the prominent cardiac feature at the time of diagnosis. Treatment guidelines of Kawasaki disease were reviewed in the light of this recent outbreak of patients presenting with MIS-C.

Other topics that have been addressed in this paper are the routine use of angiotensin-converting enzyme inhibitors (ACEI) in patients with single ventricle, as well as that of pulmonary artery banding in infants and children with end-stage dilated cardiomyopathy, in addition to cardiac resynchronization therapy. Lastly, the use of physical exercise in Fontan patients has been discussed before ending with an historical overview of the major advances made in congenital heart disease.

We present the case report of a 28-year-old man admitted to the emergency department for acute hepatitis due to nasal cocaine use. Cocaine abuse is associated with a variety of acute medical complications. Acute hepatitis without other systemic disorders is a rare condition that may occur following cocaine use.

Based on a systematic review of the literature, this report seeks to discuss the clinical, biological, and histopathological features of this disease and its evolution, too. The clinical practice guidelines for managing acute hepatitis due to cocaine use will be discussed, as well.

This case provides us the opportunity to remember and explore the differential diagnosis of acute hepatitis and the usefulness of a precise anamnesis.