Liraglutide, an analog of glucagon-like peptide (GLP)-1, prescribed to date in Type 2 diabetes mellitus at 0.6-1.8mg /day (Victoza®) is now available for the treatment of excess weight at a dose of 3mg/day (Saxenda®). Besides the insulinostimulating properties responsible for its anti-hyperglycemic activity, the drug exerts an anorectic action at the hypothalamus level, thereby promoting weight loss. Liraglutide 3mg is indicated for the treatment of obesity (BMI> 30Kg/m2) or overweight (BMI>27Kkg/m2) in patients with at least one comorbid condition. The agent's exact place in the treatment of obesity, particularly in the long-term, remains to be further specified.
Due to the development and approval of new oral anticoagulants (NOACs), the treatment of venous thromboembolic disease (VTE) has changed dramatically over the last years. Our therapeutic habits are evolving, thus raising new issues, especially regarding the use of NOACs in daily practice. The first part of this paper reviews major clinical trials that have led to the approval of NOACs for VTE treatment. In the second part, the international expert Giancarlo Agnelli shares his experiences and recommendations regarding the use of NOACs in VTE.
Hydrocephalus, a common condition in the pediatric population due to its various etiologies, proves to be an issue in many cases, due to its various etiologies, thereby threatening the children's life-expectancy and neurodevelopmental outcome...
Induced pain is defined as short-lasting pain caused by the practitioner in predictable circumstances, potentially prevented by appropriate analgesia or sedation...
Raphaël Lattenist, Daniel Léonard, Radu Bachmann, Christophe Remue, Nora Abbes Orabi, Anne Jouret-Mourin, Olivier Dewit, Pierre Hoang, Hubert Piessevaux, Eleonora Farinella, Alex KartheuserPublished in the journal : June 2016Category : Mémoires de Recherche Clinique
Total proctocolectomy followed by ileal pouch-anal anastomosis (IPAA) is currently the gold standard in the treatment of familial adenomatous polyposis (FAP) and ulcerative colitis (UC)...
While forced displacement is associated with an increased risk of tuberculosis (TB) transmission, this study sought to assess the results of a contact-tracing (CT) program implemented by the Jordan National Tuberculosis Program (NTP) among Syrian refugees in Jordan.
Laurent Guillaume, Benoit Bihin, Philippe Eucher, Yves Louagie, Erwin Schröeder, Michel BuchePublished in the journal : June 2016Category : Mémoires de Recherche Clinique
This study aimed to analyze the short- and long-term prognosis of patients subjected to aortic valve replacement using a mechanical prosthesis...
Anna Dietz, Siham Lazam, Patrick Montant, Fabien Chenot, Jamila Boulif, Christophe de Meester, David Vancraeynest, Anne-Catherine Pouleur, Bernhard Gerber, Agnès Pasquet, Jean-Louis VanoverscheldePublished in the journal : June 2016Category : Mémoires de Recherche Clinique
Severe degenerative mitral regurgitation (MR) is a progressive disease that impairs long-term prognosis...
Jessica de Jesus Azevedo, MC. Chiti, MM. Dolmans, R. Orellana, M. Soares, F. Paulini, J. Donnez, CA. AmorimPublished in the journal : June 2016Category : Mémoires de Recherche Clinique
Thousands of women suffering from malignant diseases can now be treated by chemotherapy, radiotherapy or bone marrow transplantation...
Post-transplantation lymphoproliferative disease (PTLD) is a serious complication in liver-transplanted children, most often related to Epstein-Barr virus (EBV) infection...