An umbilical lesion must be taken seriously by the practitioner, since it represents a neoplasm in two-thirds of cases, while being either a primary cancer or metastatic disease. Sister Marie-Joseph's nodule is a rare umbilical metastatic lesion, occurring in 1 to 3% of abdominopelvic adenocarcinomas. Its discovery should lead to performing an abdominopelvic scanner and skin biopsy. Therapeutic options include surgery or chemotherapy, but most often, management consists of palliative care. As for its oncological history, this nodule is characterized by its late appearance, and it has been associated with a poor prognosis.