Patient blood management is a multidisciplinary approach that aims to personalize and optimize transfusion. In addition to the obvious benefit to the patient, applying this methodology reduces the overall consumption of blood components. A collateral effect observed is a disproportionate reduction in all blood components according to blood type, with a negligible reduction effect on O-Rh-negative red cell concentrates, thereby unbalancing the supply chain. This could herald a chronic shortage of these products. As a result, is appears essential to rebalance blood component needs and resources by working on three levers of action, which involve reducing demand, reducing waste, and optimizing supply.