Kawasaki disease is the leading cause of acquired heart disease in children. Its incidence is underestimated in infants aged less than 1 year. In this population, clinical manifestations are atypical. The diagnosis should therefore be suspected in infants with persistent fever, even if not all clinical signs are present, in order to avoid delaying the diagnosis and treatment and prevent harmful cardiovascular consequences. Echocardiography is a helpful diagnostic tool and should be performed promptly in case of Kawasaki disease suspicion.
Over the past few years, clinical research dedicated to preclinical Alzheimer’s disease has considerably intensified. In vivo markers of Alzheimer’s disease paved the way for (1) studies investigating the association between pathology and cognitive decline and (2) the launch of the very first preventive trials. Besides brain autopsy, cerebrospinal fluid analyses along with amyloid- and tau-specific radiotracers are now used to detect Alzheimer’s disease. Further advances are expected in coming years, with an improved specificity of tau tracers, novel therapeutic targets, and a continuing increase in our understanding of Alzheimer’s biological processes.
A fixed combination product, composed of atorvastatin, perindopril and amlodipine, such as that used in the ASCOT study, has just been marketed by the Servier company under the trade name LIPERTANCE®. This provides us the opportunity to recall the usefulness of this double approach targeting both high blood pressure and high cholesterol levels in cardiovascular prevention. The ASCOT study has definitely proven the remarkable cardiovascular benefit of this combination in primary prevention for hypertensive patients with moderately-high cholesterol levels. Key Words cardiovascular disease, cardiovascular prevention, hypercholesterolemia, high blood pressure, LDL cholesterol, atherosclerosis
Guillain-Barré syndrome (GBS) and its clinical variants (paraparetic variant, Miller Fisher syndrome, bifacial weakness with paresthesias) are rather well-known medical afflictions nowadays.
The purpose of this historical master thesis is to rediscover the medical semiology of the neurosyphilis during the XIXth and XXth centuries and to see its evolution up to the present day.
Jean Ruwet, Dorota Tassigny, Maxime Delavallée, Anne Jeanjean, Christian RaftopoulosPublished in the journal : June 2017Category : Mémoires de Recherche Clinique
Implantation of deep brain stimulation of the subthalamic nucleus is a recognized treatment for medically intractable Parkinson’s disease.
Laure Boutsen, Ivan Borbath, Anne Jouret-Mourin, Aline Van Maanen et Birgit WeynandPublished in the journal : June 2017Category : Mémoires de Recherche Clinique
In the WHO 2010 classification, resection specimens of pancreatic neuroendocrine tumors (pNETs) are graded using the Ki67-labeling index (Ki67-LI) (G1 : Ki67-LI < 2% ; G2 : 3-20%, G3 : > 20%).
Cédric Trefois, Daniel Léonard, Audrey Hartman, Christophe Remue, Radu Bachmann, Nora Abbes Orabi, Fernande Lois, Patrice Forget, Alex KartheuserPublished in the journal : June 2017Category : Mémoires de Recherche Clinique
Fast Track (FT) is a multimodal perioperative approach which aims to optimize physiologic response to the surgical stress and consequently improve postoperative outcome.