Thousands of women suffering from malignant diseases can now be treated by chemotherapy, radiotherapy or bone marrow transplantation...

Cirrhotic children who are waitlisted for liver transplantation are prone to bleeding from ruptured esophageal varices, with Grade 2-3 varices and red signs as known risk factors...

CADASIL disease is a rare autosomal dominant hereditary angiopathy, primarily characterized by significant white matter damage on MRI. We have herein described a case of Cadasil disease discovered somewhat fortuitously, owing to its insidious symptom onset and the causal mutation 's strongly suspected transmission to the patient’s son.

Precocious puberty (PP) is a most common condition encountered in pediatric endocrinology practice. Articles reporting on increasingly early pubertal development have recently been published in the lay press, thus resulting in numerous questions from parents regarding their children's pubertal development. PP can be defined as the onset of secondary sexual characteristics, along with accelerated growth and bone maturation, occurring earlier than usual, e.g., prior to the age of 8 years in girls and 9 in boys. PP etiologies can be divided into gonadotropinreleasing hormone (GnRH)-dependent and GnRH-independent causes. GnRHdependent PP, often referred to as central PP, is usually treated using GnRHagonists.