In patients with type 2 diabetes, sulfonylureas are a therapeutic option as dual antihyperglycemic therapy following metformin failure or as a tritherapy approach.
This paper sought to provide a state-of-the-art review on sulfonylureas in the year 2018, with their indications, benefits, and side effects, which differ depending on the agent used.
What does this article bring up for us?
Sulfonylureas are a well-known conventional treatment in type 2 diabetes. This paper sought to highlight new clinical and scientific data in this field to better define the agents’ current place in the management of type 2 diabetes. The specificity of gliclazide is discussed as well.
Key Words
Sulfonylureas, glycemic control, mechanisms of action, side effects, cardiovascular, cancer