Several innovations in dermatology in 2021 should be mentioned, particularly in the field of inflammatory and immunological diseases, such as atopic dermatitis, chronic urticaria, alopecia areata or Behçet's disease, but also in oncodermatology.

For the past few years, advances have been made in atopic dermatitis leading to a better understanding of the pathogenesis, identification of comorbidities, and emergence of new biological treatments.

In the course of the year 2021, international guidelines for chronic urticaria clarified the classification and therapeutic management of this disease.

Treatment of patients with alopecia areata became more promising through the advent of Janus kinases inhibitors, leading to encouraging results.

Apremilast became a new treatment option being reimbursed for oral ulcers in Behçet's disease.

In onco-dermatology, several new developments in both diagnosis and management were made:

- Reflectance confocal microscopy is a non-invasive optical imaging technique that was made available for managing patients with suspected malignant skin lesions;

- Chlormethine, a local chemotherapy gel, was shown to be effective and is thus being reimbursed for treating cutaneous T-cell lymphoma mycosis fungoides type in adult patients;

- Simulated daylight-mediated photodynamic therapy is a new technique, which was made available for the therapeutic arsenal designed to manage transplant patients with actinic keratoses.

Skin manifestations are considered uncommon presentations of COVID-19. Despite reported cases in the literature, no causal link has been formally demonstrated to date. Skin lesions associated with COVID-19 are: 1) rashes that are classically viral or paraviral in nature like exanthemas, urticaria, and erythema multiforme; 2) eruptions that are secondary to the systemic consequences of COVID-19 like vasculitis or thrombotic vasculopathy; 3) rashes induced by drugs prescribed as part of COVID-19; 4) skin lesions like chilblains that are likely to be an indirect consequences of COVID-19 and containment measures.

We herein report on the “Peau’se dermatologique” meeting held on June 3rd, 2019 in the Cliniques universitaires Saint-Luc, Brussels, and focused on dermatological manifestations of systemic diseases. Professor Camille Francès, member of the Dermatology department at Hôpital Tenon in Paris, presented eight interesting clinical cases of systemic diseases with associated dermatological features.

We herein report on the «PEAUse dermatologique» meeting of the Cliniques universitaires Saint-Luc held on May 14, 2018, which was focused on the topic “dermatology and internal medicine”.

For this occasion, Professor Didier Bessis, head of the Dermatology department of the CHU Montpellier and specialist in the care of rare dermatological diseases, presented us some clinical cases and four examples of new clinical entities in dermatology.